Heterogeneity of marker expression in B-cell leukemias and its diagnostic significance.

Abstract

Lymphoproliferative disorders of B-cell origin are identified by surface immunoglobulin markers. Clinically, these include several types of leukemias and lymphomas. We have attempted to further characterize B-cell leukemias immunologically using monoclonal antibodies Leu-1 and FMC-7. While cases of classical B-CLL have been shown to react with Leu-1 monoclonal, most other B-cell leukemias often do not react with Leu-1. Our results show that use of an additional monoclonal FMC-7 does not contribute towards diagnostic reliability.

• Authors: M Menon, H G Drexler, J Minowada
• Journal: Leukemia research (Leuk Res) Vol. 10 Issue 1 Pg. 25-8 ( 1986) ISSN: 0145-2126 [Print] England
• PMID: 3080642 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm
• Antigens, Surface

Topics

• Antibodies, Monoclonal (immunology)
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Neoplasm (analysis)
• Antigens, Surface (analysis)
• B-Lymphocytes (immunology)
• Humans
• Leukemia (diagnosis, immunology)
• Lymphoma (immunology)