Acrodermatitis continua of Hallopeau is a chronic, inflammatory, and relapsing condition that presents as pustules of the fingers and toes, often with nail involvement. This condition is infrequently reported, difficult to treat, and often misdiagnosed. Various anti-psoriatic
therapies have been used, but literature is limited to case studies with equivocal results.
Biological therapy is revolutionizing the management of many dermatologic conditions and is believed to be a promising option for
acrodermatitis continua of Hallopeau patients who have failed conventional
therapy. We report the 4-year treatment course of a 70-year-old woman with
acrodermatitis continua of Hallopeau that was initially unsuccessful with conventional treatments but successfully treated with the
tumor necrosis factor alpha inhibitor
adalimumab, in combination with
alitretinoin and
clobetasol propionate. This case adds to the current understanding of
acrodermatitis continua of Hallopeau and the potential of
biological therapy, in our case,
adalimumab, for
acrodermatitis continua of Hallopeau management. Literature should continue growing to ascertain the safety and efficacy of
biologic therapy for patients with
acrodermatitis continua of Hallopeau.