Usefulness of PY 108-068, a new calcium channel blocker, for angina pectoris.

Abstract

The efficacy of PY 108-068 (75 and 150 mg/day), a new dihydropyridine calcium antagonist, was compared with placebo for treatment of chronic stable angina. Twelve patients were studied in a placebo-controlled, double-blind, randomized, crossover trial of 2 weeks each. Antianginal efficacy was assessed by the number of episodes of angina and nitroglycerin tablets consumed during each 2-week period, as well as the number of episodes of ischemia during 48-hour ambulatory monitoring and the area and severity of ST-segment depression during 16-point precordial exercise mapping. Nitroglycerin consumption (mean +/- standard error of the mean) decreased from 6.1 +/- 2.9 with placebo to 1.8 +/- 1.5 with 75 mg/day of PY 108-068 (p less than or equal to 0.03) and to 3.6 +/- 2.3 with 150 mg/day of PY 108-068 (p less than or equal to 0.01 vs placebo, difference not significant vs 75 mg/day of PY 108-068), whereas episodes of angina were reduced significantly only by the high dose (p less than or equal to 0.03) (11.1 +/- 3.9 with placebo, 6.3 +/- 2.4 with 75 mg/day of PY 108-068 and 8.1 +/- 3.4 with 150 mg/day of PY 108-068). The low dose alone significantly reduced ST-segment depression during exercise testing (p less than or equal to 0.03) (29.6 +/- 3.6 with placebo, 23.1 +/- 5.6 with 75 mg/day of PY 108-068 and 24.4 +/- 5.0 with 150 mg/day of PY 108-068), whereas neither dose significantly altered the number of episodes of ischemia during ambulatory monitoring.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: M de Buitleir, S Krikler, D M Krikler
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 57 Issue 1 Pg. 15-9 (Jan 01 1986) ISSN: 0002-9149 [Print] United States
• PMID: 3079940 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Blockers
• Tablets
• Nitroglycerin
• Nifedipine
• darodipine

Topics

• Aged
• Angina Pectoris (drug therapy, physiopathology)
• Calcium Channel Blockers (therapeutic use)
• Clinical Trials as Topic
• Coronary Disease (physiopathology)
• Double-Blind Method
• Electrocardiography
• Exercise Test
• Female
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Monitoring, Physiologic
• Nifedipine (administration & dosage, analogs & derivatives, therapeutic use)
• Nitroglycerin (administration & dosage)
• Random Allocation
• Tablets