[Effect of highly purified thymus factor on the cellular and humoral indices of immunity in thymectomized mice].

Abstract

Effect of homogeneous polypeptide thymus factor of mol weight about 5000 (thymarin-III) on cellular and humoral immune responses of thymectomized adult CBA mice was studied. Thymectomy proved to greatly decrease the number of T-cells in the spleen. Accordingly, the capability of these mice to produce both IgM and IgG antibody-forming cells in response to the thymus-dependent antigen (sheep red blood cells) was significantly depressed. Subcutaneous injections of thymarin-III (1 microgram per g of body weight) for 7 days completely restored the T-cell spleen population and normalized the animals' immune response.

• Authors: G A Belokrylov, V G Morozov, V Kh Khavinson, B N Sofronov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 86 Issue 7 Pg. 51-53 ( 1978) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie vysokoochishchennogo faktora timusa na kletochnye i gumoral'nye pokazateli immuniteta u timéktomirovannykh mysheĭ.
• PMID: 307966 (Publication Type: English Abstract, Journal Article)

Chemical References

• Agglutinins
• Hemagglutinins
• Thymus Extracts

Topics

• Agglutinins (biosynthesis)
• Animals
• Antibody-Producing Cells
• Cell Count
• Hemagglutinins (biosynthesis)
• Lymph Nodes (immunology)
• Male
• Mice
• Mice, Inbred CBA
• Spleen (immunology)
• T-Lymphocytes (immunology)
• Thymectomy
• Thymus Extracts (pharmacology)