Abstract | AIMS: METHODS: Seven single nucleotide polymorphisms (SNPs) of the PPARγ gene and 5 SNPs of the AGTR1 gene were selected and genotyped in 1591 unrelated Chinese adults. The SNPAssoc package of R was used to examine the relationships between the selected SNPs and NAFLD. RESULTS: After adjusting the covariance, the results from the overdominant model showed that participants carrying the T/C genotype of rs2638360 in AGTR1 have a decreased risk of NAFLD compared with those with T/T-C/C genotypes (odds ratio: 0.70, 95% confidence interval: 0.49-1.00). However, our results showed that none of the selected PPARγ variants were significantly associated with the risk of NAFLD after applying a false discovery rate correction. Among the 12 selected SNPs from PPARγ and AGTR1, model-based multifactor dimensionality reduction (MB-MDR) analyses for gene-gene interactions revealed that all the models were significantly associated with the increased risk of NAFLD (p < 0.05) except the 2-, 10-, 11-, and 12-locus models. Further, among the 10 SNPs negatively associated with NAFLD, the four-locus model (rs13431696 and rs3856806 in PPARγ, and rs5182, rs1492100 in ATGR1) and the five-locus model (rs9817428, rs1175543, rs13433696, and rs2920502 in PPARγ, and rs1492100 in ATGR1) were closely related with NAFLD susceptibility (p = 0.019 and p = 0.048, respectively). CONCLUSION: Our present study suggests that interactions among multiple AGTR1 and PPARγ polymorphisms are associated with the risk of NAFLD in the Chinese population.
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Authors | Peifu Zhu, Honghong Lu, Yang Jing, Hui Zhou, Yi Ding, Jie Wang, Daoxia Guo, Zhirong Guo, Chen Dong |
Journal | Genetic testing and molecular biomarkers
(Genet Test Mol Biomarkers)
Vol. 23
Issue 3
Pg. 166-175
(Mar 2019)
ISSN: 1945-0257 [Electronic] United States |
PMID | 30793973
(Publication Type: Journal Article)
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Chemical References |
- AGTR1 protein, human
- PPAR gamma
- Receptor, Angiotensin, Type 1
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Topics |
- Adult
- Alleles
- Asian People
(genetics)
- Case-Control Studies
- China
- Epistasis, Genetic
- Female
- Gene Frequency
(genetics)
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Humans
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(etiology, genetics)
- Odds Ratio
- PPAR gamma
(genetics, physiology)
- Polymorphism, Single Nucleotide
(genetics)
- Receptor, Angiotensin, Type 1
(genetics, physiology)
- Risk Factors
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