Abstract | BACKGROUND: METHODS: We performed a cross-sectional study in 197 mother-newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism. RESULTS: BW was positively correlated with maternal age (p = 0.021) and the educational level (p = 0.002), and negatively correlated with smoking status in pregnant women (p < 0.001). The MMP9 rs17577 variant genotypes in mothers led to a lower BW (p = 0.049). The mothers with a variant genotype of ADRA2A rs553668 gene polymorphism had newborns with a higher BW (p = 0.030). MWG and gestational age (GesAge) influenced BW (p < 0.05). We noticed that newborns' variant genotype of MMP9 rs17577 was related to a significant increase in BW (p = 0.010), while the newborns who carried the variant genotype of MMP9 rs17576 expressed a negative correlation, decreasing the BW (p = 0.032). CONCLUSION: Our study emphasizes the role of MMP9 rs17577, MMP9 rs17576, and ADRA2A rs553668 SNPs in BW determinism.
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Authors | Cristina Oana Mărginean, Claudiu Mărginean, Claudia Bănescu, Lorena Elena Meliţ, Florin Tripon, Mihaela Iancu |
Journal | Pediatric research
(Pediatr Res)
Vol. 85
Issue 6
Pg. 822-829
(05 2019)
ISSN: 1530-0447 [Electronic] United States |
PMID | 30791043
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ADRA2A protein, human
- Receptors, Adrenergic, alpha-2
- MMP9 protein, human
- Matrix Metalloproteinase 9
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Topics |
- Adult
- Birth Weight
(genetics)
- Cross-Sectional Studies
- Female
- Gestational Weight Gain
(genetics)
- Humans
- Infant Nutritional Physiological Phenomena
(genetics)
- Infant, Newborn
- Male
- Maternal Nutritional Physiological Phenomena
(genetics)
- Maternal-Fetal Exchange
(genetics)
- Matrix Metalloproteinase 9
(genetics)
- Models, Genetic
- Nutritional Status
(genetics)
- Polymorphism, Single Nucleotide
- Pregnancy
- Receptors, Adrenergic, alpha-2
(genetics)
- Romania
- Young Adult
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