Abstract | OBJECTIVES: MATERIALS AND METHODS: Patients aged 18-65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6-8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Enrolled patients were monitored every 8 ± 1 h for phlebitis using visual infusion phlebitis scale. The primary aim was to compare the proportion of patients with Grade 0, I, and II phlebitis at the end of 72 h of treatment period. RESULTS: Number of patients assessed for eligibility was 110; 26 excluded and 84 randomized. Analysis was done for 41 administered heparin QPS and 33 administered heparin gel as the rest were lost to follow-up. No phlebitis was reported in 32% of patients in QPS group and 9% in GEL group (P =0.0019). Proportion of patients with Grade I and Grade II phlebitis was 22.9% and 13.5% with QPS and 35.13% and 22.97% with gel, respectively, and the difference was statistically significant. Mean time to develop Grade I (Group QPS = 59.7 h; Group GEL = 58.46 h; P = 0.949) and Grade II (Group QPS = 62.4 h; Group GEL = 61.17 h; P = 0.732) phlebitis was comparable no adverse effects were reported in either group. CONCLUSION:
Heparin QPS was more effective in he prevention of infusion-associated phlebitis with similar safety profile as heparin gel.
|
Authors | Vikas Saini, Tanvir Samra, Nitin Ahuja, Sameer Sethi |
Journal | Indian journal of pharmacology
(Indian J Pharmacol)
2018 Nov-Dec
Vol. 50
Issue 6
Pg. 344-349
ISSN: 1998-3751 [Electronic] India |
PMID | 30783328
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Drug Carriers
- Gels
- Pharmaceutical Solutions
- Heparin
|
Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Aged
- Cannula
(adverse effects)
- Drug Carriers
(chemistry)
- Female
- Gels
(chemistry)
- Heparin
(administration & dosage, therapeutic use)
- Humans
- Infusions, Intravenous
(adverse effects, instrumentation)
- Male
- Middle Aged
- Pharmaceutical Solutions
(chemistry)
- Phlebitis
(etiology, prevention & control)
- Prospective Studies
- Treatment Outcome
- Young Adult
|