Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.

Abstract

One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.

• Authors: E T Bope, R C Adams, S C Brewer, C B Cairns, N R Fosnaugh, P C Leidheiser Jr, C W Platt, J S Polsley, R R Romaker, S D Scarbrough
• Journal: Family practice research journal (Fam Pract Res J) Vol. 7 Issue 4 Pg. 197-204 ( 1988) ISSN: 0270-2304 [Print] United States
• PMID: 3075410 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Indoles
• Hydrochlorothiazide
• tripamide

Topics

• Antihypertensive Agents (administration & dosage, pharmacology, therapeutic use)
• Family Practice
• Female
• Humans
• Hydrochlorothiazide (administration & dosage, pharmacology, therapeutic use)
• Hypertension (drug therapy)
• Indoles (administration & dosage, pharmacology, therapeutic use)
• Male
• Multicenter Studies as Topic
• Private Practice
• Random Allocation