Abstract |
In order to determine the indications of chemosensitivity tests against various anticancer agents, clinical trials of 4 different assays, namely; nude mouse isotope assay ( NMIA), subrenal capsule assay (SRCA), human tumor clonogenic assay ( HTCA) and adenosine triphosphate inhibition assay (ATPA), were performed on 391 patients. Analysis of the correlation between assay results and clinical effects presented the possibility of determining the indications as follows; (1) The positive clinical response of mitomycin C (MMC) should be predicted by ATPA; (2) The clinical tumor resistance against MMC should be predicted by SRCA; (3) Concerning 5-fluorouracil (5-FU) the chemosensitivity test (ATPA) should only be used for the detection of tumor resistance in the assay; (4) The poor results of this study indicated the difficulty of correctly estimating the effects of cyclophosphamide (CPM); (5) The perfect prediction of clinical effects in this trial indicated that cis-DDPlatinum (CDDP) should be estimated by SRCA; (6) The positive clinical tumor response against adriamycin (ADM) should be predicted by SRCA, while the negative one should be predicted by HTCA; and (7) ATPA showed good potential for estimating not only time dependent drugs such as 5-FU, but also cytotoxic drugs.
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Authors | M Nishiyama, S Takagami, Y Kirihara, T Saeki, K Niimi, Y Nosoh, N Hirabayashi, M Niimoto, T Hattori |
Journal | The Japanese journal of surgery
(Jpn J Surg)
Vol. 18
Issue 6
Pg. 647-52
(Nov 1988)
ISSN: 0047-1909 [Print] Japan |
PMID | 3073241
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Adenosine Triphosphate
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Topics |
- Adenosine Triphosphate
(pharmacology)
- Animals
- Antineoplastic Agents
(pharmacology)
- Clinical Trials as Topic
- Drug Screening Assays, Antitumor
- Humans
- Mice
- Mice, Nude
- Predictive Value of Tests
- Subrenal Capsule Assay
- Tumor Cells, Cultured
(drug effects)
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