Abstract |
The effects of clonidine or relaxation therapy were determined in two separate groups of patients with primary hypertension. Ten patients were treated with clonidine monotherapy for 3 months. There were concurrent reductions of blood pressure, plasma and CSF norepinephrine, all p less than 0.01. The changes of blood pressure and norepinephrine were correlated, p less than 0.05 and 0.01, respectively. Thirty patients received hygienic instructions, and 17 of them had relaxation training in addition. Relaxation lowered blood pressures, p less than 0.01, the reduction of blood pressure was related to baseline plasma norepinephrine, p less than 0.05, and greater in patients with "raised" plasma norepinephrine, p less than 0.02. Plasma norepinephrine was lowered after hygienic therapy, p less than 0.05, the change was not significant after relaxation training. Arterial pressure elevation appears to be related to raised plasma norepinephrine. This noradrenergic hyperactivity is a marker for blood pressure responsiveness to sympatholytic therapy with clonidine or relaxation techniques.
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Authors | D D Lee, V DeQuattro, G C Davison, S Kimura, R Barndt, P Sullivan |
Journal | Clinical and experimental hypertension. Part A, Theory and practice
(Clin Exp Hypertens A)
Vol. 10 Suppl 1
Pg. 225-34
( 1988)
ISSN: 0730-0077 [Print] United States |
PMID | 3072125
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Aged
- Blood Pressure
- Clonidine
(administration & dosage, therapeutic use)
- Combined Modality Therapy
- Female
- Humans
- Hypertension
(physiopathology, therapy)
- Male
- Middle Aged
- Norepinephrine
(metabolism)
- Relaxation Therapy
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