Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial.

Abstract

BACKGROUND:

To evaluate the efficacy and safety of intravenous Ferric Carboxymaltose. (FCM) in comparison with intravenous Iron sucrose complex (ISC) for treatment of iron deficiency anemia in pregnancy.

METHODS:

A randomized clinical trial was conducted from (January 2016-August 2017). at a tertiary hospital. Pregnant women diagnosed with moderate to severe iron deficiency anaemia were screened for the study. One hundred patients were randomized to receive either intravenous FCM or ISC. Primary outcome was rise in hemoglobin (Hb) from baseline after 12 weeks. Secondary outcomes were change in RBC indices, serum iron studies, improvement in fatigue scores, number of visits and perinatal outcome.

RESULTS:

Mean rise in Hb at 12 weeks was significantly higher in FCM group (29 g/L vs 22 g/L; p value < 0.01). FCM was associated with greater improvement in fatigue scores. Number of visits were significantly less in FCM group. No serious adverse events were noted in either group.

CONCLUSION:

Treatment with FCM resulted in rapid replenishment of iron stores in pregnant women with significantly higher Hb rise over a 12 week period. The convenient dosing with lesser number of total doses to complete the treatment will lead to better compliance in community setting. CLINICAL TRIAL REGISTRATION ( WWW.CTRI.NIC.IN ): CTRI/2015/09/006224. Registered on 21/07/2017 (Trial registered retrospectively).

• Authors: Ambily Jose, Reeta Mahey, Jai Bhagwan Sharma, Neerja Bhatla, Renu Saxena, Mani Kalaivani, Alka Kriplani
• Journal: BMC pregnancy and childbirth (BMC Pregnancy Childbirth) Vol. 19 Issue 1 Pg. 54 (Feb 04 2019) ISSN: 1471-2393 [Electronic] England
• PMID: 30717690 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Ferric Compounds
• Hematinics
• Hemoglobins
• ferric carboxymaltose
• Maltose
• Iron
• Ferric Oxide, Saccharated

Topics

• Administration, Intravenous
• Adult
• Anemia, Iron-Deficiency (blood, drug therapy)
• Erythrocyte Count
• Female
• Ferric Compounds (administration & dosage)
• Ferric Oxide, Saccharated (administration & dosage)
• Hematinics (administration & dosage)
• Hemoglobins (metabolism)
• Humans
• India
• Iron (blood)
• Maltose (administration & dosage, analogs & derivatives)
• Pregnancy
• Pregnancy Complications (blood, drug therapy)
• Prenatal Care (methods)
• Treatment Outcome
• Young Adult