Abstract | OBJECTIVES: To examine plasma levels of dichlorodiphenyldichloroethene ( DDE) and dichlorodiphenyltrichloroethane ( DDT) in association with survival among women with breast cancer who participated in a population-based case-control study. METHODS: Participants included 456 white and 292 black women from the Carolina Breast Cancer Study Phase I who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had available DDE/ DDT and lipid measurements from blood samples obtained on average 4.1 months after diagnosis. Using the National Death Index, we identified 392 deaths (210 from breast cancer) over a median follow-up of 20.6 years. We used Cox regression to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and breast cancer-specific 5-year mortality, and 20-year mortality conditional on 5-year survival, for lipid-standardized DDE and DDT levels. Associations stratified by race and estrogen receptor (ER) status were also examined. RESULTS: The highest versus lowest DDE tertile and the highest vs non-detectable DDT quantile were associated with HRs of 1.95 (95% CI = 1.31-2.92) and 1.64 (95% CI = 1.10-2.44), respectively, for 20-year conditional all-cause mortality. DDE levels above versus below the median were associated with a HR of 1.69 (95% CI = 1.06-2.68) for 20-year conditional breast cancer-specific mortality among women overall, and HRs were 2.36 (95% CI = 1.03-5.42) among black women and 1.57 (95% CI = 0.86-2.89) among white women (PInteraction = 0.42), and 3.24 (95% CI = 1.38-7.58) among women with ER- tumors and 1.29 (95% CI = 0.73-2.28) among women with ER+ tumors (PInteraction = 0.03). CONCLUSION:
|
Authors | Humberto Parada Jr, Xuezheng Sun, Chiu-Kit Tse, Lawrence S Engel, Andrew F Olshan, Melissa A Troester |
Journal | Environment international
(Environ Int)
Vol. 125
Pg. 161-171
(04 2019)
ISSN: 1873-6750 [Electronic] Netherlands |
PMID | 30716576
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Pesticides
- Dichlorodiphenyl Dichloroethylene
- DDT
|
Topics |
- Black or African American
- Breast Neoplasms
(blood, etiology, mortality)
- Cancer Survivors
- Case-Control Studies
- DDT
(blood, toxicity)
- Dichlorodiphenyl Dichloroethylene
(blood, toxicity)
- Female
- Humans
- Middle Aged
- North Carolina
- Pesticides
(blood, toxicity)
- Proportional Hazards Models
- Survival Analysis
- White People
|