Abstract | OBJECTIVE: METHODS: A finger with a subcutaneous gouty tophus and a calcified knee meniscus excised at the time of surgery were obtained. The finger was imaged using plain x-ray, dual-energy CT (DECT), and multi-energy SPCCT. Plain x-ray and multi-energy SPCCT images of the meniscus were acquired. For validation purposes, samples of the crystals were obtained from the tophus and meniscus, and examined by polarized light microscopy and/or x-ray diffraction. As further validation, synthetic crystal suspensions of MSU, CPP, and HA were scanned using multi-energy SPCCT. RESULTS: Plain x-ray of the gouty finger revealed bone erosions with overhanging edges. DECT and multi-energy SPCCT both showed MSU crystal deposits; SPCCT was able to show finer detail. Plain x-ray of the calcified meniscus showed chondrocalcinosis consistent with CPP, while SPCCT showed and differentiated CPP and HA. CONCLUSION: Multi-energy SPCCT can not only detect, differentiate, and quantify MSU crystal deposits in a gouty finger ex vivo, but also specifically detect, identify, and quantify CPP within an osteoarthritic meniscus, and distinguish them from HA crystal deposits. There is potential for multi-energy SPCCT to become useful in the diagnosis of crystal arthropathies.
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Authors | Lisa K Stamp, Nigel G Anderson, Fabio Becce, Maya Rajeswari, Matthew Polson, Olivier Guyen, Anais Viry, Chloe Choi, Tracy E Kirkbride, Aamir Y Raja |
Journal | Arthritis & rheumatology (Hoboken, N.J.)
(Arthritis Rheumatol)
Vol. 71
Issue 7
Pg. 1158-1162
(07 2019)
ISSN: 2326-5205 [Electronic] United States |
PMID | 30714678
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019, American College of Rheumatology. |
Chemical References |
- Uric Acid
- Durapatite
- Calcium Pyrophosphate
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Topics |
- Calcium Pyrophosphate
- Chondrocalcinosis
(diagnostic imaging)
- Crystal Arthropathies
(diagnostic imaging)
- Diagnosis, Differential
- Durapatite
- Fingers
(diagnostic imaging, pathology)
- Gout
(diagnostic imaging)
- Humans
- Menisci, Tibial
(diagnostic imaging, pathology)
- Radiography
- Tomography, X-Ray Computed
(methods)
- Uric Acid
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