Abstract | OBJECTIVE: METHODS:
Status Epilepticus (SE) was induced by Li-Pc in five experimental groups: 24 h after SE, all rats received twice daily either a low (10 mg/kg) or high (20 mg/kg) dose of LTG, or a low (25 mg/kg) or high (50 mg/kg) dose of ESM, or solvent. The sixth group (control) did not receive Li-Pc and was given twice daily injections with solvent only. Drug administration lasted for 7 d. Rats were systematically observed in the 5th and 6th weeks, after that the brains were prepared for histology. RESULTS: LTG dose-dependently decreased the frequency of SRS, and restricted neuronal loss, as well as astrogliosis in the hippocampus compared with the untreated SE control group. However, ESM had none of the above-mentioned effects. CONCLUSION: LTG had protective as well as disease-modifying effects in this TLE model. It was revealed that the disease-modifying effects were accompanied by the prevention of neuronal loss and astrogliosis. ESM was devoid of antiepileptogenic and its accompanying histological effects in this TLE model, in contrast to the antiepileptogenic effects found in the genetic absence epilepsy models, suggesting that different mechanisms are involved in the different models for epileptogenesis and antiepileptogenesis.
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Authors | Jie Wang, Yanjun Chen, Qiong Wang, Gilles van Luijtelaar, Meizhen Sun |
Journal | Brain research
(Brain Res)
Vol. 1712
Pg. 1-6
(06 01 2019)
ISSN: 1872-6240 [Electronic] Netherlands |
PMID | 30707894
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Anticonvulsants
- Neuroprotective Agents
- Pilocarpine
- Ethosuximide
- Lithium
- Lamotrigine
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Topics |
- Animals
- Anticonvulsants
(pharmacology)
- Disease Models, Animal
- Electroencephalography
(methods)
- Epilepsy, Temporal Lobe
(drug therapy, metabolism)
- Ethosuximide
(metabolism, pharmacology)
- Female
- Gliosis
(pathology)
- Hippocampus
(drug effects)
- Lamotrigine
(metabolism, pharmacology)
- Lithium
(pharmacology)
- Neurons
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Pilocarpine
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Seizures
(chemically induced, pathology)
- Status Epilepticus
(pathology)
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