Abstract | INTRODUCTION: The regulation of apoptosis via compounds originated from marine organisms signifies a new wave in the field of drug discovery. Marine organisms produce potent compounds as they hold the phenomenal diversity in chemical structures. The main focus of drug development is anticancer therapy. METHODS: Expertise on manifold activities of compounds helps in the discovery of their derivatives for preclinical and clinical experiment that promotes improved activity of compounds for cancer patients. RESULTS: These marine derived compounds stimulate apoptosis in cancer cells by targeting Bcl-2 and Survivin, highlighting the fact that instantaneous targeting of these proteins by novel derivatives results in efficacious and selective killing of cancer cells. CONCLUSION:
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Authors | Eram Shakeel, Rajnish Kumar, Neha Sharma, Salman Akhtar, Mohd Kalim Ahmad Khan, Mohtashim Lohani, Mohd Haris Siddiqui |
Journal | Current computer-aided drug design
(Curr Comput Aided Drug Des)
Vol. 15
Issue 3
Pg. 265-276
( 2019)
ISSN: 1875-6697 [Electronic] United Arab Emirates |
PMID | 30706824
(Publication Type: Journal Article)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Antineoplastic Agents
- Proto-Oncogene Proteins c-bcl-2
- Survivin
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, pharmacology)
- Aquatic Organisms
(chemistry)
- Drug Discovery
- Drug Screening Assays, Antitumor
- Molecular Docking Simulation
- Molecular Targeted Therapy
- Proto-Oncogene Proteins c-bcl-2
(chemistry, metabolism)
- Survivin
(chemical synthesis, chemistry, pharmacology)
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