NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia.

Abstract

Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. High levels of serum NMDAR antibodies were found, suggesting NMDARE. Immunosuppressive treatment gradually eliminated the NMDA receptor antibodies. Our case extends the clinical spectrum associated with neuronal cell-surface autoantibodies to include atypical cases of TEA.

• Authors: Sharon A Savage, Sarosh R Irani, M Isabel Leite, Adam Z Zeman
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 327 Pg. 41-43 (02 15 2019) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 30686545 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Topics

• Anti-N-Methyl-D-Aspartate Receptor Encephalitis (complications)
• Epilepsy, Temporal Lobe (immunology)
• Humans
• Male
• Middle Aged