Effect of continuous venovenous haemodialysis on outcome and pharmacokinetics of arsenic species in a patient with acute promyelocytic leukaemia and acute kidney injury.

Abstract

This study presents outcome and pharmacokinetics of arsenic trioxide (ATO) metabolites in patients on continuous venovenous haemodialysis (CVVHD). Of 3 acute promyelocytic leukaemia patients receiving CVVHD in management of acute kidney injury, only 1 patient was included. The patient presented disseminated intravascular coagulation and acute kidney injury before induction therapy was conducted. CVVHD was performed and ATO was initiated. Species of ATO metabolites in plasma and effluent were analysed using high performance liquid chromatography-hydride generation-atomic fluorescence spectrometry. Plasma concentrations of AsIII , monomethylarsonic acid and dimethylarsinic acid with CVVHD were lower than those without CVVHD. Area under the concentration-time curve from 0 to the last sample with quantifiable concentration of AsIII without CVVHD was significantly higher than that with CVVHD (292.10 ng h/mL vs 195.86 ng h/mL, P = .037), which were not observed for monomethylarsonic acid and dimethylarsinic acid. Dialysate saturation of arsenic species was remarkable, especially for AsIII . Complete remission was achieved and renal function recovered. In this study, ATO can be used safely and effectively to treat acute promyelocytic leukaemia patients undergoing CVVHD without dose adjustment.

• Authors: Chunlu Gao, Shengjin Fan, Thomas H Hostetter, Wenjing Wang, Jing Li, Meihua Guo, Jin Zhou, Xin Hai
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 85 Issue 4 Pg. 849-853 (04 2019) ISSN: 1365-2125 [Electronic] England
• PMID: 30677159 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The British Pharmacological Society.

Chemical References

• Antineoplastic Agents
• Arsenic Trioxide

Topics

• Acute Kidney Injury (blood, etiology, therapy)
• Aged
• Antineoplastic Agents (administration & dosage, pharmacokinetics)
• Area Under Curve
• Arsenic Trioxide (administration & dosage, pharmacokinetics)
• Continuous Renal Replacement Therapy
• Dose-Response Relationship, Drug
• Humans
• Leukemia, Promyelocytic, Acute (blood, drug therapy)
• Male
• Prospective Studies
• Remission Induction (methods)
• Single-Case Studies as Topic
• Treatment Outcome