Abstract | BACKGROUND/OBJECTIVES: DESIGN: Observational prospective cohort. SETTING: Duke University Medical Center, Duke Regional Hospital, and Duke Raleigh Hospital. PARTICIPANTS: Patients 60 years of age or older (N = 200) undergoing noncardiac/nonneurologic surgery. MEASUREMENTS: Participants will undergo cognitive testing before, 6 weeks, and 1 year after surgery. Delirium screening will be performed on postoperative days 1 to 5. Blood and CSF samples are obtained before surgery, and 24 hours, 6 weeks, and 1 year after surgery. CSF MCP-1 levels are measured by enzyme-linked immunosorbent assay, and CSF monocytes are assessed by flow cytometry. Half the patients will also undergo pre- and postoperative functional magnetic resonance imaging scans. 32-channel intraoperative electroencephalogram (EEG) recordings will be performed to identify intraoperative EEG correlates of neuroinflammation and/or postoperative cognitive resilience. Eighty patients will also undergo home sleep apnea testing to determine the relationships between sleep apnea severity, neuroinflammation, and impaired postoperative cognition. Additional assessments will help evaluate relationships between delirium, POCD, and other geriatric syndromes. CONCLUSION:
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Authors | Miles Berger, Deborah Oyeyemi, Mobolaji O Olurinde, Heather E Whitson, Kent J Weinhold, Marty G Woldorff, Lewis A Lipsitz, Eugene Moretti, Charles M Giattino, Kenneth C Roberts, Junhong Zhou, Thomas Bunning, Michael Ferrandino, Randall P Scheri, Mary Cooter, Cliburn Chan, Roberto Cabeza, Jeffrey N Browndyke, David M Murdoch, Michael J Devinney, Leslie M Shaw, Harvey Jay Cohen, Joseph P Mathew, INTUIT Investigators |
Journal | Journal of the American Geriatrics Society
(J Am Geriatr Soc)
Vol. 67
Issue 4
Pg. 794-798
(04 2019)
ISSN: 1532-5415 [Electronic] United States |
PMID | 30674067
(Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 The American Geriatrics Society. |
Topics |
- Aged
- Delirium
(etiology)
- Encephalitis
(complications)
- Humans
- Middle Aged
- Postoperative Cognitive Complications
(etiology)
- Prospective Studies
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