Abstract | BACKGROUND: METHODS: We extracted 201 FSGS patients from 10 nephrology centers in Japan and investigated the difference of a composite renal endpoint, defined as doubling of serum creatinine and/or development of end-stage renal disease, in pathological variants. Sensitivity analysis was used to prove the utility of the Col-class to predict renal outcomes. Additionally, the renal protective effects of steroids and/or immunosuppression ( steroid/IS) were investigated in patients stratified according to the Col-class. RESULTS: The patients were classified into the following variants: not otherwise specified [NOS; n = 121 (60.1%)], perihilar [n = 31 (15.4%)], cellular [n = 19 (9.5%)], tip [n = 17 (8.5%)] and collapsing [n = 13 (6.5%)]. No tip variant patients reached the renal endpoint. The renal outcome in the collapsing variant was significantly poorer than that in the NOS [hazard ratio (HR) 3.71; P = 0.005]. In the sensitivity analysis, the area under the receiver operating characteristic curve for the renal endpoint was increased by adding Col-class to a model including common risk factors (P = 0.021). In a subgroup treated without steroid/IS, the outcome in the cellular variant was worse than that in the NOS (HR 5.10; P = 0.040) but the difference was not observed in the subgroup with steroid/IS (HR 0.54; P = 0.539). CONCLUSIONS: The Col-class is useful to predict renal prognosis in Japanese patients with FSGS. In addition to good prognosis in the tip variant and poor in the collapsing variant, good clinical course in the cellular variant treated with steroid/IS was suggested.
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Authors | Akihiro Tsuchimoto, Yuta Matsukuma, Kenji Ueki, Shigeru Tanaka, Kosuke Masutani, Kaneyasu Nakagawa, Koji Mitsuiki, Noriko Uesugi, Ritsuko Katafuchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 35
Issue 7
Pg. 1219-1227
(07 01 2020)
ISSN: 1460-2385 [Electronic] England |
PMID | 30649467
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. |
Chemical References |
- Immunosuppressive Agents
- Steroids
- Creatinine
|
Topics |
- Adult
- Aged
- Creatinine
(blood)
- Disease Progression
- Female
- Glomerulosclerosis, Focal Segmental
(classification, drug therapy, pathology)
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Kidney
(drug effects, pathology)
- Male
- Middle Aged
- Prognosis
- ROC Curve
- Retrospective Studies
- Risk Factors
- Steroids
(administration & dosage)
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