Exposure-response analysis of blinatumomab in patients with relapsed/refractory acute lymphoblastic leukaemia and comparison with standard of care chemotherapy.

Abstract

AIMS:

The relationship between blinatumomab exposure and efficacy endpoints (occurrence of complete remission [CR] and duration of overall survival [OS]) or adverse events (occurrence of cytokine release syndrome [CRS] and neurological events) were investigated in adult patients with relapsed/refractory acute lymphoblastic leukaemia (r/r ALL) receiving blinatumomab or standard of care (SOC) chemotherapy to evaluate appropriateness of the blinatumomab dosing regimen.

METHODS:

Exposure, efficacy and safety data from adult patients (n = 646) with r/r ALL receiving stepwise (9 then 28 μg/day, 4-week cycle) continuous intravenous infusion (n = 537) of blinatumomab or SOC (n = 109) chemotherapy were pooled from phase 2 and 3 studies. The occurrence of CR, neurological and CRS events, and duration of OS were analysed using Cox proportional hazards models or logistic regression, as appropriate. Confounding factors were tested multivariately as needed.

RESULTS:

Blinatumomab steady-state concentration following 28 μg/day dosing was associated with the probability of achieving CR (odds ratio and 95% confidence interval: 1.073 [1.033-1.114]), and a longer duration of OS compared to SOC (hazard ratio and 95% confidence interval: 0.954 [0.936-0.973], P < .05) in multivariate analyses. The exposure-safety analyses indicated that blinatumomab steady-state concentration following the 9 or 28 μg/day dose was not associated with increased probability of CRS or neurological events, after accounting for blinatumomab treatment effect (P > .05).

CONCLUSIONS:

Blinatumomab step-dosing regimen of 9/28 μg/day provided treatment benefit in achieving CR and increasing the duration of OS over SOC and was appropriate in management of CRS and neurological events in patients with r/r ALL.

• Authors: Mita Kuchimanchi, Min Zhu, John D Clements, Sameer Doshi
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 85 Issue 4 Pg. 807-817 (04 2019) ISSN: 1365-2125 [Electronic] England
• PMID: 30645768 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Amgen. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Chemical References

• Antibodies, Bispecific
• Antineoplastic Agents, Immunological
• blinatumomab

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antibodies, Bispecific (administration & dosage, adverse effects)
• Antineoplastic Agents, Immunological (administration & dosage, adverse effects)
• Cytokine Release Syndrome (epidemiology, etiology)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Resistance, Neoplasm
• Female
• Humans
• Infusions, Intravenous
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multicenter Studies as Topic
• Neoplasm Recurrence, Local (drug therapy, mortality)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, mortality)
• Randomized Controlled Trials as Topic
• Remission Induction (methods)
• Standard of Care
• Time Factors
• Young Adult