Culture-Proven Endophthalmitis After Intravitreal Injection: A 10-Year Analysis.

Abstract

BACKGROUND AND OBJECTIVE:

To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-associated, culture-proven endophthalmitis.

PATIENTS AND METHODS:

All patients seen at a tertiary referral center with culture-proven endophthalmitis associated with an IVI between June 2007 and July 2017 were included in this retrospective analysis.

RESULTS:

Thirty-five patients with culture-positive endophthalmitis following IVI were identified. All gram-positive organisms (34 of 35) were susceptible to vancomycin. Cases due to pathogens associated with oral or respiratory flora were common (31.4%, n = 11), presented earlier (2.0 days vs. 4.6 days, P < .001), were more likely to undergo pars plana vitrectomy (81.8% vs. 25.0%, P = .002) and had worse visual acuity outcomes.

CONCLUSION:

IVI-associated endophthalmitis pathogens and anti-microbial susceptibilities in the Pacific Northwest are similar to those reported from other geographic locations. Bacteria associated with the oral and respiratory flora are common isolates that result in a more aggressive course and worse visual outcomes. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:33-38.].

• Authors: Joseph M Simonett, Austin Igelman, Stanford C Taylor, J Peter Campbell, Thomas S Hwang, Phoebe Lin, Andreas K Lauer, Christina J Flaxel
• Journal: Ophthalmic surgery, lasers & imaging retina (Ophthalmic Surg Lasers Imaging Retina) Vol. 50 Issue 1 Pg. 33-38 (01 01 2019) ISSN: 2325-8179 [Electronic] United States
• PMID: 30640393 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2019, SLACK Incorporated.

Chemical References

• Anti-Bacterial Agents
• Vancomycin

Topics

• Aged
• Anti-Bacterial Agents (administration & dosage)
• Endophthalmitis (diagnosis, microbiology, therapy)
• Eye Infections, Bacterial (diagnosis, microbiology, therapy)
• Female
• Follow-Up Studies
• Forecasting
• Gram-Negative Bacteria (isolation & purification)
• Gram-Negative Bacterial Infections (diagnosis, microbiology, therapy)
• Humans
• Male
• Retrospective Studies
• Vancomycin (administration & dosage)
• Visual Acuity
• Vitrectomy (methods)