Anti-Dengue, Cytotoxicity, Antifungal, and In Silico Study of the Newly Synthesized 3-O-Phospo-α-D-Glucopyranuronic Acid Compound.

Abstract

The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound 7 (methyl 3-O-phospo-α-D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various in vitro biological screening. The results showed that compound 7 has promising antifungal activity against selected fungal strains. Computational study was also carried out to find antimalarial efficacy of the synthesized compounds. Compounds (2-7) were tested for cytotoxicity by MTT assay, and no considerable cytotoxicity was observed. Molecular docking study was performed to predict the binding modes of new compound (7). The docking results revealed that the compound has strong attraction towards the target protein, as characterized by good bonding networks. On the basis of the acquired results, it can be predicted that compound (7) might show good inhibitory activity against dengue envelope protein.

• Authors: Tareq Abu-Izneid, Abdur Rauf, Saud Bawazeer, Abdul Wadood, Seema Patel
• Journal: BioMed research international (Biomed Res Int) Vol. 2018 Pg. 8648956 ( 2018) ISSN: 2314-6141 [Electronic] United States
• PMID: 30627577 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Antiviral Agents
• Cytotoxins
• Glucuronates

Topics

• Antifungal Agents
• Antiviral Agents (chemical synthesis, chemistry)
• Computer Simulation
• Cytotoxins (chemical synthesis, chemistry)
• Dengue (drug therapy)
• Glucuronates (chemical synthesis, chemistry)
• Molecular Docking Simulation