Plasma xanthine oxidoreductase activity in patients with decompensated acute heart failure requiring intensive care.

Abstract

AIMS:

Plasma xanthine oxidoreductase (XOR) activity during the acute phase of acute heart failure (AHF) requires further elucidation.

METHODS AND RESULTS:

One hundred eighteen AHF patients and 231 control patients who attended a cardiovascular outpatient clinic were prospectively analysed. Blood samples were collected within 15 min of admission from AHF patients (AHF group) and control patients who visited a daily cardiovascular outpatient clinic (control group). Plasma XOR activity was compared between the two groups, and factors independently associated with extremely elevated XOR activity were identified using a multivariate logistic regression model. Plasma XOR activity in the AHF group (median, 104.0 pmol/h/mL; range, 25.9-423.5 pmol/h/mL) was significantly higher than that in the control group (median, 45.2 pmol/h/mL; range, 19.3-98.8 pmol/h/mL). The multivariate logistic regression model showed that serum uric acid (per 1.0 mg/dL increase, odds ratio: 1.280; 95% confidence interval: 1.066-1.536; P = 0.008) and lactate levels (per 1.0 mmol/L increase, odds ratio: 1.239; 95% confidence interval: 1.040-1.475; P = 0.016) were independently associated with high plasma XOR activity (>300 pg/h/mL) during the acute phase of AHF.

CONCLUSIONS:

Plasma XOR activity was extremely high in patients with severely decompensated AHF. This would be associated with a high lactate value and would eventually lead to hyperuricaemia in patients with AHF.

• Authors: Hirotake Okazaki, Akihiro Shirakabe, Masato Matsushita, Yusaku Shibata, Tomofumi Sawatani, Saori Uchiyama, Kennichi Tani, Takayo Murase, Takashi Nakamura, Tsutomu Takayasu, Miwako Asano, Nobuaki Kobayashi, Noritake Hata, Kuniya Asai, Wataru Shimizu
• Journal: ESC heart failure (ESC Heart Fail) Vol. 6 Issue 2 Pg. 336-343 (Apr 2019) ISSN: 2055-5822 [Electronic] England
• PMID: 30620450 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

Chemical References

• Biomarkers
• Uric Acid
• Xanthine Dehydrogenase

Topics

• Acute Disease
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Critical Care (methods)
• Female
• Follow-Up Studies
• Heart Failure (blood, complications, therapy)
• Humans
• Hyperuricemia (blood, etiology)
• Male
• Prognosis
• Prospective Studies
• Severity of Illness Index
• Uric Acid (blood)
• Xanthine Dehydrogenase (blood)