Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials.

Abstract

PURPOSE:

To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness).

METHODS:

Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-DL-leucine, Acetyl-leucine. Trial selection: randomised controlled trials (RCTs) comparing acetylleucine against placebo.

RESULTS:

Up until 2018, no RCTs have been published on the efficacy of acetylleucine in vertigo/dizziness.

CONCLUSION:

There is no solid evidence of the efficacy of acetylleucine in vertigo/dizziness. Given its frequent prescription and the cost generated for the French social security system, high-quality randomised trials should be carried out to assess its efficacy.

• Authors: Paul Vanderkam, Clara Blanchard, Florian Naudet, Denis Pouchain, Helene Vaillant Roussel, Marie Christine Perault-Pochat, Nematollah Jaafari, Rémy Boussageon
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 75 Issue 5 Pg. 603-607 (May 2019) ISSN: 1432-1041 [Electronic] Germany
• PMID: 30613860 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Leucine
• acetylleucine

Topics

• Dizziness (drug therapy)
• Humans
• Leucine (analogs & derivatives, therapeutic use)
• Randomized Controlled Trials as Topic
• Vertigo (drug therapy)