Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: This study was aimed to provide comprehensive evidence for the anti-cachectic effect of a modified Sijunzi decoction (Zhen-Qi; ZQ-SJZ) and characterize its anti-cachectic mechanism, especially in cisplatin-induced muscle atrophy. MATERIALS AND METHODS: We employed a Lewis lung carcinoma (LLC)-induced cancer cachectic mouse model to demonstrate the anti-cachectic effect of ZQ-SJZ. Moreover, we provided an in vitro C2C12 myotube formation model to investigate the effect of ZQ-SJZ in hampering cisplatin-induced muscle atrophy. RESULTS: The administration of ZQ-SJZ can recover tumor- and/or cisplatin-induced body weight loss, intestinal mucosal damage, as well as forelimb grip strength and myofiber size. The administration of ZQ-SJZ also significantly prolonged the survival of LLC-induced cachectic mice under cisplatin treatment. Mechanistically, ZQ-SJZ increased the levels of myogenic proteins, such as myosin heavy chain (MyHC) and myogenin, and decreased the atrophy-related protein, atrogin-1, in cisplatin-treated C2C12 myotubes in vitro. In addition, cisplatin-induced mitochondria dysfunction could be hampered by the co-administration of ZQ-SJZ, by which it recovered the cisplatin-mediated decrease in PGC-1α and PKM1 levels. CONCLUSIONS: The administration of ZQ-SJZ can recover tumor- and/or cisplatin-induced cachectic conditions and significantly prolong the survival of LLC-induced cachectic mice under cisplatin treatment. The profound effect of ZQ-SJZ in hampering tumor- and/or cisplatin-induced cachexia may be due to its modulation of the mitochondrial function and subsequent myogenesis. Taken together, these results demonstrated the anti-cachectic mechanism of ZQ-SJZ and its potential use as a palliative strategy to improve the efficacy of chemotherapy.
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Authors | Jing-Ming Chen, Ting-Ting Yang, Tai-Shan Cheng, Ting-Fen Hsiao, Peter Mu-Hsin Chang, Jyh-Yih Leu, Feng-Sheng Wang, Shih-Lan Hsu, Chi-Ying F Huang, Jin-Mei Lai |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 233
Pg. 47-55
(Apr 06 2019)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 30590199
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Drugs, Chinese Herbal
- Sijunzi decoction
- Cisplatin
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Topics |
- Animals
- Antineoplastic Agents
(adverse effects)
- Cachexia
(drug therapy)
- Carcinoma, Lewis Lung
(drug therapy)
- Cell Line
- Cisplatin
(adverse effects)
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Female
- Mice, Inbred C57BL
- Muscular Atrophy
(drug therapy)
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