Increase in vascular permeability of rat and guinea pig skin by T-kinin.

Abstract

The vascular permeability-increasing response to T-kinin in rat and guinea pig skin was investigated. The vascular permeability was measured with 125I-labeled bovine serum albumin [( 125I]BSA) as a tracer. Plasma exudation rapidly occurred 0-15 min after the intradermal injection of T-kinin. T-kinin in doses of 0.3, 1, and 3 nM/spot significantly increased the vascular permeability in a dose-dependent manner. The vascular response of T-kinin is similar to that of bradykinin. On the other hand, T-kinin analogs, D-Ile-Ser-bradykinin and Ile-D-Ser-bradykinin only weakly enhanced the vascular permeability. Prostaglandin E1, forskolin, and the angiotensin-converting enzyme inhibitor, SQ-14225, potentiated the T-kinin-induced plasma exudation. Cyproheptadine and indomethacin did not affect the T-kinin-induced response. The results suggest that T-kinin will play an important role in increasing vascular permeability associated with inflammation.

• Authors: K Sugio, L M Greenbaum
• Journal: Inflammation (Inflammation) Vol. 12 Issue 5 Pg. 407-12 (Oct 1988) ISSN: 0360-3997 [Print] United States
• PMID: 3058606 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Colforsin
• T-kinin
• Captopril
• Alprostadil
• Bradykinin

Topics

• Alprostadil (pharmacokinetics, pharmacology)
• Animals
• Bradykinin (analogs & derivatives, pharmacokinetics, pharmacology)
• Capillary Permeability (drug effects)
• Captopril (pharmacokinetics, pharmacology)
• Colforsin (pharmacokinetics, pharmacology)
• Dose-Response Relationship, Drug
• Exudates and Transudates (drug effects)
• Guinea Pigs
• Rats
• Rats, Inbred Strains
• Skin (blood supply, drug effects)