Abstract |
Based on the benefit of polyphenolic compounds on osteoporosis, we hypothesized that the polyphenol-rich herbal congee containing the combined extract of Morus alba and Polygonum odoratum leaves should improve bone turnover markers in menopausal women. To test this hypothesis, a randomized double-blind placebo-controlled study was performed. A total of 45 menopausal participants were recruited in this study. They were randomly divided into placebo, D1, and D2 groups, respectively. The subjects in D1 and D2 groups must consume the congee containing the combined extract of M. alba and P. odoratum leaves at doses of 50 and 1500 mg/day, respectively. At the end of an 8-week consumption period, all subjects were determined serum bone markers including calcium, alkaline phosphatase, osteocalcin, and beta CTX. In addition, the hematological and blood clinical chemistry changes, and total phenolic content in the serum were also determined. The results showed that the menopausal women in D2 group increased serum alkaline phosphatase, osteocalcin, and total phenolic compounds content but decreased CTX level. Clinical safety assessment failed to show toxicity and adverse effects. Therefore, herbal congee containing the combined extract of M. alba and P. odoratum leaves is the potential functional food that can decrease the risk of osteoporosis.
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Authors | Jintanaporn Wattanathorn, Woraluk Somboonporn, Sudarat Sungkamanee, Wipawee Thukummee, Supaporn Muchimapura |
Journal | Oxidative medicine and cellular longevity
(Oxid Med Cell Longev)
Vol. 2018
Pg. 2091872
( 2018)
ISSN: 1942-0994 [Electronic] United States |
PMID | 30584459
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- Plant Extracts
- Polyphenols
- Osteocalcin
- Alkaline Phosphatase
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Topics |
- Alkaline Phosphatase
(blood)
- Biomarkers
(blood)
- Bone Density
(drug effects)
- Double-Blind Method
- Humans
- Menopause
(blood, drug effects)
- Morus
(chemistry)
- Osteocalcin
(blood)
- Perimenopause
(blood, drug effects)
- Plant Extracts
(chemistry, pharmacology)
- Plant Leaves
(chemistry)
- Polygonum
(chemistry)
- Polyphenols
(chemistry, pharmacology)
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