Abstract | OBJECTIVE: STUDY DESIGN: Cases (n = 5 556) comprised all women in Denmark aged 30-84 years with a histologically verified first diagnosis of epithelial ovarian cancer during 2000-2015. Age-matched population controls (n = 83 340) were selected using risk-set sampling. Data on prescription use, patient and demographic characteristics were retrieved from nationwide registries. MAIN OUTCOME MEASURES: RESULTS: Ever use of antihistamines was not associated with ovarian cancer overall (OR = 0.97, 95% CI = 0.90-1.05). The lack of association remained in subanalyses for patterns of antihistamine use. We observed an inverse association between antihistamine use and ovarian cancer among pre-menopausal women (<50 year: OR = 0.72, 95% CI = 0.57-0.90), but not post-menopausal women (≥50 year: OR = 1.02, 95%CI = 0.93-1.11). In analyses of histological subtypes, an inverse association emerged for mucinous ovarian cancer (OR = 0.74, 95% CI = 0.57-0.96), but not for other subtypes. CONCLUSION:
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Authors | Freija Verdoodt, Anton Pottegård, Christian Dehlendorff, Marja Jäättelä, Jesper Hallas, Søren Friis, Susanne K Kjaer |
Journal | Maturitas
(Maturitas)
Vol. 120
Pg. 47-52
(Feb 2019)
ISSN: 1873-4111 [Electronic] Ireland |
PMID | 30583764
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Adenocarcinoma, Mucinous
(epidemiology)
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Ovarian Epithelial
(epidemiology)
- Case-Control Studies
- Denmark
(epidemiology)
- Female
- Histamine Antagonists
(therapeutic use)
- Humans
- Middle Aged
- Ovarian Neoplasms
(epidemiology)
- Postmenopause
- Premenopause
- Registries
- Risk Factors
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