Abstract |
The results of 6 clinical trials involving a total of 174 patients are reported. Levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526) was compared in double-blind manner with placebo, morclofone and cloperastine. The antitussive activity and therapeutic efficacy of the drug were shown to be greater than those of placebo and morclofone and similar to those of cloperastine. Levodropropizine was effective in about 80% of patients; in responders, cough frequency was reduced by an average of 33-51%. Levodropropizine was generally well tolerated and mild side-effects were reported for only 3% of patients.
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Authors | L Allegra, R Bossi |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 38
Issue 8
Pg. 1163-6
(Aug 1988)
ISSN: 0004-4172 [Print] Germany |
PMID | 3058135
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Antitussive Agents
- Benzophenones
- Piperidines
- Propylene Glycols
- cloperastine
- dipropizine
- morclofone
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antitussive Agents
(adverse effects, therapeutic use)
- Benzophenones
(therapeutic use)
- Bronchitis
(drug therapy)
- Clinical Trials as Topic
- Cough
(drug therapy)
- Double-Blind Method
- Drug Tolerance
- Female
- Humans
- Male
- Middle Aged
- Multicenter Studies as Topic
- Piperidines
(therapeutic use)
- Propylene Glycols
(adverse effects, therapeutic use)
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