| Abstract | A study of individual response factors to the anti-inflammatory drug Diclofenac, as carried out in 3,123 patients, selected by 200 french rheumatism specialists. The efficacy was evaluated with a visual analogous scale and the patients were classified by the quartile method into 4 types of responses: for 3 patients out of 4, the response is better than 5/10 and for 1 in every 2 patients, better than 7/10. Among the 24 factors that were tested concerning the efficacy, 14 could significantly predict this efficacy. Then, correspondance analyses have enabled to grade the relative role of these prognostic factors. 4 of them seem to have a prevailing role: the number of previous treatments with non steroid anti-inflammatory drugs, the duration of the disease, the diagnosis and finally, the finding of psychic disorders before treatment. It is suggested that the result of a treatment with non steroid anti-inflammatory drugs is not a variable phenomenon and that some prognostic factors could be taken into account in therapeutic trials. |
| Authors | M J Gérard
(Affiliation: Laboratoire Ciba-Geigy, Rueil-Malmaison.)
|
| Journal | Revue du rhumatisme et des maladies ostéo-articulaires
(Rev Rhum Mal Osteoartic)
Vol. 55
Issue 10
Pg. 735-9
(Oct 1988)
ISSN: 0035-2659 FRANCE |
| Vernacular Title | Variations individuelles dans la réponse aux anti-inflammatoires non stéroïdiens. |
| PMID | 3057606
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Diclofenac
|
| Topics |
- Adult
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Diclofenac
(therapeutic use)
- Drug Evaluation
- Female
- Humans
- Male
- Middle Aged
- Prognosis
- Rheumatic Diseases
(drug therapy)
|
