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Acute myeloid leukemia with eosinophilia after cyclin-dependent kinases 4/6 inhibitor treatment due to underlying clonal hematopoiesis of indeterminate potential.

AuthorsKartik Anand, Praveen Kumar, Sai Ravi Pingali, Debananda Pati, Swaminathan P Iyer
JournalAmerican journal of hematology (Am J Hematol) Vol. 94 Issue 3 Pg. E82-E85 (03 2019) ISSN: 1096-8652 [Electronic] United States
PMID30575100 (Publication Type: Case Reports, Letter, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminopyridines
  • Antigens, Nuclear
  • Antineoplastic Agents
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • Protein Kinase Inhibitors
  • Purines
  • Rad21 protein, mouse
  • STAG2 protein, human
  • Granulocyte Colony-Stimulating Factor
  • CDK4 protein, human
  • CDK6 protein, human
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • ribociclib
Topics
  • Adult
  • Aminopyridines (adverse effects)
  • Animals
  • Antigens, Nuclear (genetics, metabolism)
  • Antineoplastic Agents (adverse effects)
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase 4 (antagonists & inhibitors, genetics, metabolism)
  • Cyclin-Dependent Kinase 6 (antagonists & inhibitors, genetics, metabolism)
  • DNA-Binding Proteins
  • Disease Models, Animal
  • Eosinophilia (chemically induced, genetics, metabolism, pathology)
  • Female
  • Granulocyte Colony-Stimulating Factor (adverse effects)
  • Hematopoiesis (drug effects, genetics)
  • Humans
  • Leukemia, Myeloid, Acute (chemically induced, genetics, metabolism, pathology)
  • Mice
  • Mutation
  • Nuclear Proteins (deficiency, genetics)
  • Phosphoproteins (deficiency, genetics)
  • Protein Kinase Inhibitors (adverse effects)
  • Purines (adverse effects)

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