Investigation of the prolonged hypoglycemic effect of human proinsulin in diabetes mellitus.

Abstract

Human proinsulin possesses a clear hypoglycemic effect, the extent and kinetics of which were investigated in 8 insulin dependent diabetics. In addition, to adequate therapy with a controlled-release insulin, each patient received i.v. injections of insulin (e U) and proinsulin (9 U) on separate test days. After 9 U of proinsulin, the blood glucose decrease was delayed in comparison to 3 U of insulin. However, it reached identical maximum blood glucose decrease values. The elimination kinetics of proinsulin are delayed compared to insulin. There is a linear relation between the time and the reciprocal value of the measured insulin immuno-reactivity. The hypoglycemic effect of proinsulin which is protracted for hours corresponds to that of an extreme controlled-release insulin. Under certain conditions, proinsulin might therefore prove effective in the long-term treatment of the insulin-dependent diabetes mellitus.

• Authors: H Laube, W Pinter, K Federlin
• Journal: Hormone and metabolic research. Supplement series (Horm Metab Res Suppl) Vol. 18 Pg. 12-5 ( 1988) ISSN: 0170-5903 [Print] Germany
• PMID: 3056806 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Glucose
• C-Peptide
• Insulin
• Proinsulin

Topics

• Adult
• Aged
• Blood Glucose (metabolism)
• C-Peptide (blood)
• Diabetes Mellitus, Type 1 (blood, drug therapy)
• Humans
• Insulin (blood, pharmacokinetics, therapeutic use)
• Kinetics
• Middle Aged
• Proinsulin (pharmacokinetics, therapeutic use)