Central retinal thickness following panretinal photocoagulation using a multispot semi-automated pattern-scanning laser to treat ischaemic diabetic retinopathy: Treatment in one session compared with four monthly sessions.

Abstract

PURPOSE:

To compare central retinal thickness (CRT) after panretinal photocoagulation (PRP) with a multispot semi-automated PAttern-SCAnning Laser (PASCAL) in one session (SS-PRP) versus four monthly sessions (MS-PRP) in diabetic retinopathy.

METHODS:

Multicentre, prospective, randomized, single-blinded, controlled trial evaluating the noninferiority of SS-PRP versus MS-PRP for CRT measured with macular spectral-domain optical coherence tomography (SD-OCT), with a 9-month follow-up in patients presenting severe nonproliferative diabetic retinopathy (DR) or mild proliferative DR without macular oedema (ME) at baseline.

RESULTS:

Ninety-seven eyes of 97 participants with a mean age of 57.0 ± 14.2 years were included. The mean change of CRT from baseline to 9 months was not statistically different in SS-PRP or in MS-PRP: +16.9 ± 28.3 μm versus +24.7 ± 31.8 μm, respectively (p = 0.224). The variation in mean best-corrected visual acuity (BCVA) from baseline to 9 months was similar in both groups: -1.1 ± 6.5 letters versus -0.6 ± 6.2 letters (p = 0.684). The number of patients with stabilization of DR was not statistically different between the two groups. No severe complication was recorded in either group.

CONCLUSION:

This study showed the noninferiority of PRP performed in one session versus four monthly sessions with a PASCAL concerning central retinal thickness for treating mild proliferative or severe nonproliferative DR without ME at baseline.

• Authors: Pierre-Henry Gabrielle, Pascale Massin, Laurent Kodjikian, Ali Erginay, Charlotte Pallot, Lysiane Jonval, Agnès Soudry, Aude Couturier, Cristina Vardanian-Vartin, Alain M Bron, Catherine Creuzot-Garcher
• Journal: Acta ophthalmologica (Acta Ophthalmol) Vol. 97 Issue 5 Pg. e680-e687 (Aug 2019) ISSN: 1755-3768 [Electronic] England
• PMID: 30561087 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: © 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Topics

• Diabetic Retinopathy (diagnosis, physiopathology, surgery)
• Disease Progression
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Humans
• Laser Coagulation (methods)
• Male
• Middle Aged
• Postoperative Period
• Prospective Studies
• Retina (pathology, surgery)
• Single-Blind Method
• Time Factors
• Tomography, Optical Coherence (methods)
• Treatment Outcome
• Visual Acuity