HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

DOX Loaded Aggregation-induced Emission Active Polymeric Nanoparticles as a Fluorescence Resonance Energy Transfer Traceable Drug Delivery System for Self-indicating Cancer Therapy.

Abstract
In this study, an AIE-active polymer (FTP) was successfully prepared and employed to load anti-cancer drug doxorubicin (DOX) for self-indicating cancer therapy via dual FRET process. Our results demonstrated that the FTP polymer could self-assemble into nanoparticles (NPs) in aqueous solutions to give strong fluorescence emission via intramolecular FRET process. The DOX loaded FTP NPs (drug loading content: 21.77%) were homogeneous particles with size around 50 nm and neutral surface charge, which showed preferable colloidal stability, hemolysis and selective drug release with comparable in vivo antitumor effects to DOX·HCl. In particular, the FRET process between FTP (donor) and DOX (acceptor) could serve as indicator for monitoring the in vitro and in vivo drug release profile, which might be a promising platform to realize real-time monitoring of drug localization and release during the delivery process. STATEMENT OF SIGNIFICANCE: 1. An amphiphilic polymer containing aggregation-induced emission segments and polyethylene glycol (PEG) chains (FTP) was firstly synthesized, which is capable of exerting strong fluorescence via intramolecular Förster resonance energy transfer (FRET) in the aggregate state. 2. The FTP polymer could self-assembled into homogeneous nanoparticles in aqueous environment with decent DOX loading capacity. 3. The DOX loaded FTP nanoparticles can afford FRET-traceable monitoring of the drug release both in vitro and in vivo.
AuthorsCheng Wang, Ziyu Wang, Xin Zhao, Fangying Yu, Yiwu Quan, Yixiang Cheng, Hong Yuan
JournalActa biomaterialia (Acta Biomater) Vol. 85 Pg. 218-228 (02 2019) ISSN: 1878-7568 [Electronic] England
PMID30557697 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Colloids
  • Polymers
  • Doxorubicin
Topics
  • Animals
  • Body Weight
  • Cell Death (drug effects)
  • Colloids (chemistry)
  • Doxorubicin (pharmacology, therapeutic use)
  • Drug Delivery Systems
  • Drug Liberation
  • Female
  • Fluorescence Resonance Energy Transfer
  • Hemolysis
  • Humans
  • MCF-7 Cells
  • Mice, Inbred BALB C
  • Mice, Nude
  • Nanoparticles (chemistry)
  • Neoplasms (drug therapy, pathology)
  • Polymers (chemical synthesis, chemistry)
  • Rabbits
  • Tumor Burden

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: