Smart wound dressing based on κ-carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections.

Abstract

A smart wound dressing based on carrageenan (κC), locust bean gum (LBG), and cranberry extract (CB) for monitoring bacterial wound infections was developed and characterized using UV-vis spectroscopy, FT-IR, and SEM. The mechanical, swelling, cytotoxic and pH sensor properties were also investigated. UV-vis spectra demonstrated that the obtained κC:LBG:CB hydrogel film exhibited a visible change of colors as it was immersed in PBS solution pH 5.0, 7.3 and 9.0. The spectra of FT-IR suggested that chemical interactions had occurred between κC and CB extract. The obtained κC:LBG:CB hydrogel film exhibited adequate mechanical properties and a swelling behavior dependent on pH. Cytotoxicity tests indicated that κC:LBG:CB hydrogel film had dose-dependent cytotoxicity against NIH 3T3 fibroblast cells. The in vitro studies using Staphylococcus aureus and Pseudomonas aeruginosa demonstrated that the color changes of the κC:LBG:CB hydrogel film could be observed by naked eyes, confirming the potential use of the obtained hydrogel film as a visual system for monitoring bacterial wound infections.

• Authors: Karine Modolon Zepon, Maryane Modolon Martins, Morgana Souza Marques, Julia Maia Heckler, Fernando Dal Pont Morisso, Marina Griebeler Moreira, Ana Luiza Ziulkoski, Luiz Alberto Kanis
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 206 Pg. 362-370 (Feb 15 2019) ISSN: 1879-1344 [Electronic] England
• PMID: 30553333 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Anthocyanins
• Anti-Bacterial Agents
• Galactans
• Hydrogels
• Indicators and Reagents
• Mannans
• Plant Extracts
• Plant Gums
• Carrageenan
• locust bean gum

Topics

• Animals
• Anthocyanins (chemistry, pharmacology, toxicity)
• Anti-Bacterial Agents (chemistry, pharmacology, toxicity)
• Bacterial Infections (diagnosis)
• Bandages
• Carrageenan (chemistry, toxicity)
• Color
• Elastic Modulus
• Galactans (chemistry, toxicity)
• Hydrogels (chemistry, toxicity)
• Hydrogen-Ion Concentration
• Indicators and Reagents (chemistry, pharmacology, toxicity)
• Mannans (chemistry, toxicity)
• Mice
• NIH 3T3 Cells
• Plant Extracts (chemistry, pharmacology, toxicity)
• Plant Gums (chemistry, toxicity)
• Pseudomonas aeruginosa (drug effects)
• Staphylococcus aureus (drug effects)
• Tensile Strength
• Vaccinium macrocarpon (chemistry)
• Wound Infection (diagnosis)