Objective:To explore the effect of
butylphthalide on oxidative stress and cognitive function in old
obstructive sleep apnea hypopnea syndrome (
OSAHS)patients.Method:A total of 90 old
OSAHS patients with
cognitive impairment were choosed with Polysomnography(PSG). By random number table method
OSAHS patients were randomly divided into non-invasive
ventilator group (
n=30),
butylphthalide with non-invasive
ventilator group(
n=30) and treatment group of
butylphthalide(
n=30). Non-invasive
ventilator group was given
continuous positive airway pressure treatment for three months,
butylphthalide with non-invasive
ventilator group accepted oral
butylphthalide therapy and
continuous positive airway pressure treatment for three months, treatment group of
butylphthalide only accepted oral
butylphthalide therapy for three months. Cognitive function of three groups wered observed by the Montreal cognitive assessment scale (MoCA) before and
after treatment, at the same time, the changes of serum
superoxide dismutase(SOD) and
malondialdehyde(MDA) were detected by immunoenzyme-linked adsorption.Result:The differences of serum SOD and MDA before treatment among the three groups were not statistically significant (P>0.05). Compared with before treatment, the level of serum SOD increased and the level of MDA decreased in the three groups (P<0.05). Compared with non-invasive
ventilator group after treatment,the level of SOD increased and the level of MDA decreased in
butylphthalide with non-invasive
ventilator group (P<0.05), the level of SOD decreased and the level of MDA increased in treatment group of
butylphthalide (P<0.05). Compared with treatment group of
butylphthalide after treatment, the level of SOD increased and the level of MDA decreased in
butylphthalide with non-invasive
ventilator group (P<0.05); The scores of MoCA on cognitive function before treatment in the three groups was not statistically significant (P>0.05).
After treatment the scores of MoCA on cognitive function in the three groups were higher than those before treatment (P<0.05). Compared with non-invasive
ventilator group after treatment, the scores of MoCA increased in
butylphthalide with non-invasive
ventilator group (P<0.05),the the scores of MoCA decreased in treatment group of
butylphthalide (P<0.05). Compared with treatment group of
butylphthalide after treatment, the scores of MoCA increased in
butylphthalide with non-invasive
ventilator group (P<0.05).Conclution:
Butylphthalide can improve the activity of
antioxidant enzymes in the serum of old patients with
OSAHS, inhibit the
oxygen free radical and lipid peroxidation and to a certain extent improve the cognitive function.