Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta.
|
| Abstract |
Eleven patients undergoing operation on the descending or thoracoabdominal aorta were administered papaverine intrathecally in an attempt to protect the spinal cord from ischemic damage. Concurrently, 19 patients, also undergoing operation on the thoracic or thoracoabdominal aorta, were operated on with a variety of conventional techniques, including distal aortic perfusion, but were not given intrathecal papaverine. No signs of early neurologic injury developed in any of the patients in the intrathecal papaverine group, although delayed paraparesis developed in one of the patients (9%; 70% confidence limits = 1% to 28%). On the other hand, eight of 19 patients undergoing operation with conventional techniques had either lower extremity paraparesis or paraplegia postoperatively (42%; 70% confidence limits = 29% to 57%; p = 0.058). Intrathecal papaverine appeared to provide spinal cord protection during thoracic aortic operations, particularly during prolonged periods of aortic cross-clamping. Papaverine was not associated with increased risk and may be superior to other conventionally used modalities. We conclude that continued evaluation of this technique is justified.
|
|---|---|
| Authors | L G Svensson, R W Stewart, D M Cosgrove 3rd, B W Lytle, M D Antunes, E G Beven, A J Furlan, A Gottlieb, D F Grum, R A Hinder |
| Journal | The Journal of thoracic and cardiovascular surgery (J Thorac Cardiovasc Surg) Vol. 96 Issue 5 Pg. 823-9 (Nov 1988) ISSN: 0022-5223 [Print] United States |
| PMID | 3054343 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!