A40926 aglycone and pseudoaglycones: preparation and biological activity.

Abstract

A40926 antibiotics are new glycopeptides which are much more active than other members of this class against Neisseria gonorrhoeae. Their activity against Gram-positive bacteria, including coagulase-negative Staphylococci, is similar to that of other glycopeptides. An A40926 preparation containing factors A and B ("A40926 A + B complex") was hydrolyzed to the aglycone and to the mannosyl and N-acylaminoglucuronyl aglycones. The mannosyl aglycone and the aglycone were less active than A40926 A + B complex against Streptococci and Gram-positive anaerobes and lost the anti-gonorrheal activity. In contrast, the N-acylaminoglucuronyl aglycones were as active as the parent complex against these Gram-positive bacteria and were moderately active against N. gonorrhoeae. The aglycone and, even more so, the N-acylaminoglucuronyl aglycones, had better activity than the parent complex against coagulase-negative Staphylococci. In experimental septicemia in the mouse, A40926 A + B complex and its derivatives had activity proportional to their MIC for the test organism.

• Authors: E Selva, B P Goldstein, P Ferrari, R Pallanza, E Riva, M Berti, A Borghi, G Beretta, R Scotti, G Romanò
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 9 Pg. 1243-52 (Sep 1988) ISSN: 0021-8820 [Print] England
• PMID: 3053550 (Publication Type: Comparative Study, Journal Article)

Chemical References

• A 40926
• Anti-Bacterial Agents
• Glycopeptides
• Peptides
• Peptides, Cyclic
• A 40926 aglycone
• Teicoplanin

Topics

• Animals
• Anti-Bacterial Agents (isolation & purification)
• Chromatography, Affinity
• Chromatography, High Pressure Liquid
• Glycopeptides (isolation & purification, pharmacology)
• Hydrolysis
• Mice
• Microbial Sensitivity Tests
• Molecular Structure
• Neisseria (drug effects)
• Peptides (isolation & purification, pharmacology)
• Peptides, Cyclic
• Staphylococcus (drug effects)
• Streptococcal Infections (drug therapy)
• Streptococcus (drug effects)
• Streptococcus pyogenes (drug effects)
• Teicoplanin (analogs & derivatives)