Abstract |
Thirteen patients with metastatic squamous cell cancer of the lung were treated, in a nonrandomized study, with an oral high-dose methotrexate and citrovorum factor rescue regimen. There was some response and/or stabilization of disease for at least three months in six (46%) of 13 cases. The median survival time of the study group was double (365 vs. 180 days) that of a retrospectively matched control group. This suggests a possible therapeutic effect of this treatment program in metastatic squamous cell cancer of the lung.
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Authors | K Tornyos, H Faust |
Journal | Cancer
(Cancer)
Vol. 41
Issue 2
Pg. 400-2
(Feb 1978)
ISSN: 0008-543X [Print] United States |
PMID | 305283
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Administration, Oral
- Adult
- Aged
- Carcinoma, Squamous Cell
(drug therapy)
- Drug Therapy, Combination
- Humans
- Leucovorin
(therapeutic use)
- Lung Neoplasms
(drug therapy)
- Methotrexate
(administration & dosage)
- Middle Aged
- Neoplasm Metastasis
(drug therapy)
- Remission, Spontaneous
- Time Factors
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