Clinical aspects of basic calcium phosphate crystal deposition.

Abstract

Our present understanding of the mechanisms of pathologic calcification is quite limited. Therefore, no reliable method exists to prevent calcium crystal deposition. Low doses of warfarin have been employed in some cases of soft tissue calcification because it depresses the synthesis of the vitamin K-dependent GLA protein (gamma carboxyglutamic acid), which has been implicated in the process of calcification. Reports of success must be tempered by the lack of a controlled study. Probenecid has also been utilized in the treatment of calcinosis.

• Authors: P B Halverson, D J McCarty
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 14 Issue 2 Pg. 427-39 (Aug 1988) ISSN: 0889-857X [Print] United States
• PMID: 3051158 (Publication Type: Journal Article, Review)

Chemical References

• Calcium Phosphates

Topics

• Arthritis (metabolism)
• Calcinosis (etiology, metabolism)
• Calcium Phosphates (metabolism)
• Crystallization
• Humans
• Joint Diseases (etiology, metabolism)
• Knee Joint
• Osteoarthritis (metabolism)
• Shoulder Joint
• Syndrome