Abstract | OBJECTIVES: METHODS:
TRAF6 rs540386 genotyping was performed by mutagenically separated PCR in a cohort of 188 (23 men, 165 women, median age, 56.2 years) adult RA patients and 224 age and gender-matched controls. BMD was measured using dual-energy X-ray absorptiometry (DXA) (Lunar Prodigy advance scans, GE Healthcare, USA). RESULTS: Among the RA patients, 64 (55 women, 9 men) had low BMD comprising of 57 patients with osteoporosis and 7 with osteopenia. Whereas TRAF6 rs540386 was not associated with RA susceptibility, it was however found to be a risk factor for reduced lumbar spine Z-score in the recessive model (OR = 3.34, 95% CI = (1.01-11.00), p = 0.038). This association was confirmed further in the multivariate logistic regression analysis taking into account several potential confounding factors (OR = 3.34 (1.01-11.00), p = 0.048). In addition, mean total femur Z-score was found to be reduced in TT patients when compared to CC + CT patients (- 1.30 ± 1.32 versus - 0.60 ± 1.05, p = 0.034). No association between TRAF6 rs540386 and local bone damage was observed. CONCLUSIONS: This study for the first time ever demonstrated an association between a genetic variant of TRAF6 and low BMD among patients with RA. Further investigations are needed to elucidate the exact role of this variant.
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Authors | Hana Ben Hassine, Ramzi Zemni, Imen Ben Nacef, Asma Boumiza, Foued Slama, Khadija Baccouche, Najla Amri, Sarra Melayah, Zahid Shakoor, Adel Almogren, Elyes Bouajina, Rim Sghiri |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 38
Issue 4
Pg. 1067-1074
(Apr 2019)
ISSN: 1434-9949 [Electronic] Germany |
PMID | 30506403
(Publication Type: Journal Article)
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Chemical References |
- TNF Receptor-Associated Factor 6
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Topics |
- Absorptiometry, Photon
- Adult
- Aged
- Alleles
- Arthritis, Rheumatoid
(diagnostic imaging, genetics)
- Bone Density
(genetics)
- Female
- Femur
(diagnostic imaging)
- Femur Neck
(diagnostic imaging)
- Gene Frequency
- Genotype
- Humans
- Lumbar Vertebrae
(diagnostic imaging)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- TNF Receptor-Associated Factor 6
(genetics)
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