Increase of scabies in Germany and development of resistant mites? Evidence and consequences.

Abstract

Scabies has been diagnosed surprisingly frequently in Germany in recent years, and the use of acaricides has risen markedly. Present figures indicate an increase in the prevalence/incidence of scabies, but do not prove or quantify it for the following reasons: (a) scabies is not a notifiable disease in Germany; (b) the diagnosis is not always confirmed lege artis by means of light microscopy or dermatoscopy (which may lead to a comparatively high proportion of false‐positive diagnoses due to the low overall prevalence of scabies); (c) repeated treatments of the same patient and treatment of contact persons are included in the total number of prescriptions. Therefore, there are no valid data on disease occurrence, either in the current situation or from previous periods. Observations of ineffective treatment with permethrin have led to speculations that Sarcoptes mites are developing resistance to this drug. However, there is little evidence for this assumption. We discuss risk groups (children, elderly people in need of care, migrant health personnel in nursing institutions, refugees, sexually active young adults) and evaluate their possible contribution, albeit in the absence of evidence. None of the groups would be solely responsible for an increased frequency. We have compiled recommendations on how the management of scabies could be improved, and present a way of differentiating permethrin resistance from application errors and/or lack of compliance. The goal is to solve the epidemiological and parasitological questions mentioned above.

• Authors: Cord Sunderkötter, Anton Aebischer, Matthias Neufeld, Christoph Löser, Alexander Kreuter, Ralf Bialek, Henning Hamm, Hermann Feldmeier
• Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (J Dtsch Dermatol Ges) Vol. 17 Issue 1 Pg. 15-23 (01 2019) ISSN: 1610-0387 [Electronic] Germany
• PMID: 30480868 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Chemical References

• Insecticides
• Permethrin
• Ivermectin

Topics

• Animals
• Germany
• Humans
• Insecticide Resistance
• Insecticides (pharmacology)
• Ivermectin (pharmacology)
• Mites (drug effects)
• Permethrin (pharmacology)
• Scabies (drug therapy, epidemiology)