Abstract | BACKGROUND:
Pesticide exposures are suspected to be implicated in the excess of central nervous system (CNS) tumours observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate insecticides, used on a wide range of crops, have shown evidence of carcinogenicity in some experimental studies. In the cohort AGRICAN (AGRIculture & CANcer), we assessed the associations between potential exposures to carbamate insecticides and the incidence of CNS tumours, overall and by histological subtype. METHODS: AGRICAN enrolled 181 842 participants involved in agriculture. Incident CNS tumours were identified by linkage with cancer registries from enrolment (2005-07) until 2013. Carbamate exposure was assessed by combining information on lifetime periods of pesticide use on crop or livestock and the French crop-exposure matrix PESTIMAT, individually for each of the 19 carbamate insecticides registered in France since 1950. Associations were estimated using proportional hazards models with age as the underlying time scale, adjusting for gender, educational level and smoking. RESULTS: CONCLUSIONS: Findings reinforce carcinogenicity evidence for already suspected active ingredients and draw attention to additional active ingredients, notably used on fruit trees, vineyards, potatoes and beets.
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Authors | Clément Piel, Camille Pouchieu, Lucile Migault, Béatrix Béziat, Mathilde Boulanger, Mathilde Bureau, Camille Carles, Anne Grüber, Yannick Lecluse, Virginie Rondeau, Xavier Schwall, Séverine Tual, Pierre Lebailly, Isabelle Baldi, AGRICAN group |
Journal | International journal of epidemiology
(Int J Epidemiol)
Vol. 48
Issue 2
Pg. 512-526
(04 01 2019)
ISSN: 1464-3685 [Electronic] England |
PMID | 30476073
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2018; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association. |
Chemical References |
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Topics |
- Adult
- Aged
- Agricultural Workers' Diseases
(chemically induced, epidemiology, pathology)
- Agriculture
- Central Nervous System Neoplasms
(chemically induced, epidemiology, pathology)
- Farmers
- Female
- France
(epidemiology)
- Humans
- Male
- Middle Aged
- Occupational Exposure
(adverse effects)
- Pesticides
(toxicity)
- Proportional Hazards Models
- Prospective Studies
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