Intake of protein-rich foods in relation to outcomes of infertility treatment with assisted reproductive technologies.

Abstract

Background:

Some dietary factors have been linked to outcomes of infertility treatment with assisted reproductive technology (ART), but the role of intake of meats and other protein-rich foods remains unclear.

Objective:

The aim of this manuscript was to study the relation between preconception intake of meat and other protein-rich foods and outcomes of infertility treatment with ART.

Design:

A total of 351 women enrolled in a prospective cohort at the Massachusetts General Hospital Fertility Center and underwent 598 ART cycles for infertility treatment. Meat intake was assessed with a validated food-frequency questionnaire, and ART outcomes were abstracted from electronic medical records. We estimated the associations between intake of protein-rich foods (meats, eggs, beans, nuts, and soy) and the outcome of live birth per initiated cycle using generalized linear mixed models.

Results:

The average total meat intake was 1.2 servings/d, with most coming from poultry (35%), fish (25%), processed meat (22%), and red meat (17%). Fish intake was positively related to the proportion of cycles resulting in live birth. The multivariable-adjusted probabilities of live birth for women in increasing quartiles of fish intake were 34.2% (95% CI: 26.5%, 42.9%), 38.4% (95% CI: 30.3%, 47.3%), 44.7% (95% CI: 36.3%, 53.4%), and 47.7% (95% CI: 38.3%, 57.3%), respectively (P-trend = 0.04). In the estimated substitution analyses, the ORs of live birth associated with increasing fish intake by 2 servings/wk were 1.54 (95% CI: 1.14, 2.07) when fish replaced any other meat, 1.50 (95% CI: 1.13, 1.98) when fish replaced any other protein-rich food, and 1.64 (95% CI: 1.14, 2.35) when fish replaced processed meat.

Conclusions:

Fish consumption is related to a higher probability of live birth following infertility treatment with ART. This trial was registered at clinicaltrials.gov as NCT00011713.

• Authors: Feiby L Nassan, Yu-Han Chiu, Jose C Vanegas, Audrey J Gaskins, Paige L Williams, Jennifer B Ford, Jill Attaman, Russ Hauser, Jorge E Chavarro, EARTH Study Team
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 108 Issue 5 Pg. 1104-1112 (11 01 2018) ISSN: 1938-3207 [Electronic] United States
• PMID: 30475972 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Dietary Proteins

Topics

• Adult
• Animals
• Diet
• Diet Surveys
• Dietary Proteins (administration & dosage)
• Feeding Behavior
• Female
• Fishes
• Hospitals
• Humans
• Infertility, Female (therapy)
• Live Birth
• Massachusetts
• Odds Ratio
• Pregnancy
• Prospective Studies
• Reproductive Techniques, Assisted
• Seafood
• Treatment Outcome