Abstract |
Although vascular endothelial growth factor ( VEGF) promotes the immunosuppressive microenvironment, the efficacy of bevacizumab (Bev) on tumor immunity has not been fully investigated. The present study used 47 glioblastoma tissues obtained at 3 different settings: tumors of initial resection (naïve Bev group), tumors resected following Bev therapy (effective Bev group), and recurrent tumors after Bev therapy (refractory Bev group). The paired samples of the initial and post-Bev recurrent tumors from 9 patients were included. The expression of programmed cell death-1 (PD-1)/PD ligand-1 (PD-L1), CD3, CD8, Foxp3, and CD163 was analyzed by immunohistochemistry. The PD-L1+ tumor cells significantly decreased in the effective or refractory Bev group compared with the naïve Bev group (P < .01 for each). The PD-1+ cells significantly decreased in the effective or refractory Bev group compared with the naïve Bev group (P < .01 for each). The amount of CD3+ and CD8+ T cell infiltration increased in the refractory Bev group compared with the naïve Bev group (CD3, P < .01; CD8, P = .06). Both Foxp3+ regulatory T cells and CD163+ tumor-associated macrophages significantly decreased in the effective or refractory Bev group compared with the naïve Bev group (Foxp3, P < .01 for each; CD163, P < .01 for each). These findings were largely confirmed by comparing paired initial and post-Bev recurrent tumors. Bevacizumab restores the immunosupportive tumor microenvironment in glioblastomas, and this effect persists during long-term Bev therapy.
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Authors | Ryota Tamura, Toshihide Tanaka, Kentaro Ohara, Keisuke Miyake, Yukina Morimoto, Yohei Yamamoto, Ryuichi Kanai, Yasuharu Akasaki, Yuichi Murayama, Takashi Tamiya, Kazunari Yoshida, Hikaru Sasaki |
Journal | Cancer science
(Cancer Sci)
Vol. 110
Issue 2
Pg. 499-508
(Feb 2019)
ISSN: 1349-7006 [Electronic] England |
PMID | 30467920
(Publication Type: Journal Article)
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Copyright | © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. |
Chemical References |
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Antineoplastic Agents, Immunological
- B7-H1 Antigen
- Biomarkers, Tumor
- CD163 antigen
- Receptors, Cell Surface
- Vascular Endothelial Growth Factor A
- Bevacizumab
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
(metabolism)
- Antigens, Differentiation, Myelomonocytic
(metabolism)
- Antineoplastic Agents, Immunological
(therapeutic use)
- B7-H1 Antigen
(immunology)
- Bevacizumab
(therapeutic use)
- Biomarkers, Tumor
(immunology)
- Brain Neoplasms
(drug therapy, immunology)
- Female
- Glioblastoma
(drug therapy, immunology)
- Humans
- Immunohistochemistry
(methods)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(immunology)
- Receptors, Cell Surface
(metabolism)
- Tumor Microenvironment
(drug effects, immunology)
- Vascular Endothelial Growth Factor A
(metabolism)
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