Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients.

Abstract

Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.

• Authors: Ching-Wei Hsu, Cheng-Hao Weng, Ming-Jen Chan, Dan-Tzu Lin-Tan, Tzung-Hai Yen, Wen-Hung Huang
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 17251 (11 22 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 30467375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Aluminum

Topics

• Adult
• Aged
• Aluminum (blood)
• Biomarkers (blood)
• Cross-Sectional Studies
• Female
• Humans
• Male
• Middle Aged
• Prevalence
• Pruritus (blood, epidemiology, etiology)
• Renal Dialysis (adverse effects)