Effect of nickel chloride on streptozotocin-induced diabetes in rats.

Abstract

The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, protein, and Cu-Zn superoxide dismutase activity. In rats treated with nickel chloride (10 mg/kg body weight) and streptozotocin, these values were comparable with those observed in control rats. The results indicate that nickel chloride injected before streptozotocin prevented streptozotocin-induced hyperglycemia, and suggest that the protective effect was related to Cu-Zn superoxide dismutase activity, mediated by copper.

• Authors: E L Novelli, N L Rodrigues, B O Ribas
• Journal: Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 66 Issue 5 Pg. 663-5 (May 1988) ISSN: 0008-4212 [Print] Canada
• PMID: 3046720 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Insulin
• nickel chloride
• Copper
• Nickel
• Superoxide Dismutase
• Ceruloplasmin
• Zinc

Topics

• Animals
• Blood Glucose (metabolism)
• Ceruloplasmin (metabolism)
• Copper
• Diabetes Mellitus, Experimental (metabolism)
• Insulin (blood)
• Nickel (pharmacology)
• Pancreas (enzymology)
• Superoxide Dismutase (metabolism)
• Zinc