Efficacy comparison of rosuvastatin and atorvastatin in the treatment of atherosclerosis and drug safety analysis.

Abstract

Previous studies have shown that the commonly used statin lipid lowering drugs can delay the progression of atherosclerotic plaque. Atorvastatin can stabilize atherosclerotic plaque, but it can not reverse atheromatous plaque. This study will compare the efficacy of rosuvastatin and atorvastatin in the treatment of atherosclerosis and try to prove that the use of statins can improve peripheral atherosclerosis and reverse atherosclerotic plaque. The results showed that 10 mg rosuvastatin was more effective than 20 mg atorvastatin in lowering serum lipid level and elevating ABI index, ABI as rosuvastatin group (0.782±0.236) and atorvastatin group(0.541±0.196). After 6 months of treatment, the carotid artery IMT in rosuvastatin group and atorvastatin group decreased compared with before treatment, and the difference was statistically significant (P<0.05). The TC/mmol⋅L-1 is 2.83±0.56 in rosuvastatin group and 3.24±0.71 in atorvastatin group. In addition, rosuvastatin did not increase the risk of adverse reactions compared with atorvastatin. The results confirm that statin therapy can improve peripheral atherosclerosis and reverse atherosclerotic plaques.

• Authors: Zeng Liping, Liu Xiufang, Yang Tao, Zhao Baomin, Tuo Houshuai
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 31 Issue 5(Special) Pg. 2203-2208 (Sep 2018) ISSN: 1011-601X [Print] Pakistan
• PMID: 30463813 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Rosuvastatin Calcium
• Atorvastatin

Topics

• Adult
• Aged
• Atherosclerosis (drug therapy)
• Atorvastatin (therapeutic use)
• Carotid Arteries (drug effects)
• Female
• Humans
• Male
• Middle Aged
• Plaque, Atherosclerotic (drug therapy)
• Rosuvastatin Calcium (therapeutic use)