Hepatocellular Carcinoma Arising in a Non-cirrhotic Liver with Secondary Hemochromatosis.

Abstract

A 70-year-old man was admitted for treatment of a single liver nodule that was detected by contrast-enhanced computed tomography. Twenty years earlier, the patient had been diagnosed with myelodysplastic syndrome-refractory anemia and secondary hemochromatosis but had not received erythrocyte transfusions. The current histological, computed tomography, and magnetic resonance imaging findings revealed hepatocellular carcinoma (HCC) and non-cirrhotic liver hemochromatosis. The liver tumor was treated using radiofrequency ablation therapy. Secondary hemochromatosis may be a risk factor for HCC, even if the liver is not cirrhotic. In such cases, additional surveillance may be required to detect the development of HCC.

• Authors: Ryo Yamauchi, Kazuhide Takata, Yoshinobu Shinagawa, Takashi Tanaka, Hiromi Fukuda, Sho Fukuda, Hideo Kunimoto, Kaoru Umeda, Daisuke Morihara, Keiji Yokoyama, Yasuaki Takeyama, Makoto Irie, Satoshi Shakado, Mikirou Mizoguchi, Satoshi Hisano, Kengo Yoshimitsu, Shotaro Sakisaka
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 58 Issue 5 Pg. 661-665 (Mar 01 2019) ISSN: 1349-7235 [Electronic] Japan
• PMID: 30449774 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Biopsy
• Carcinoma, Hepatocellular (diagnostic imaging, etiology, pathology, surgery)
• Catheter Ablation (methods)
• Hemochromatosis (complications)
• Humans
• Liver Neoplasms (diagnostic imaging, etiology, pathology, surgery)
• Magnetic Resonance Imaging
• Male
• Myelodysplastic Syndromes (complications)
• Risk Factors
• Tomography, X-Ray Computed
• Ultrasonography