Abstract |
Fifteen patients with high-risk leukaemia were given T-cell depleted marrow transplants from HLA non-identical related donors. They were treated with a combination of total body irradiation (TBI), high-dose cytosine arabinoside (Ara-C) and high-dose melphalan in an attempt to prevent a host-versus-graft reaction. Antilymphocyte globulins were given prior to transplantation for additional immunosuppression to 13 patients and in-vivo monoclonal antibody anti-human LFA1 to two. Engraftment and chimaerism assessed by HLA typing were achieved in 14 patients. Seven developed acute graft-versus-host disease (two fatal), one failed to engraft. Six patients died in complete remission from cytomegalovirus (CMV) interstitial pneumonitis and three remain alive in complete remission 2, 3 and 13 months after transplant. We conclude that aggressive immunosuppression allows for sustained engraftment of T-cell depleted HLA non-identical marrow. The incidence and severity of GVHD are acceptable and CMV pneumonitis remains the major problem.
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Authors | J Y Cahn, P Herve, M Flesch, E Plouvier, E Racadot, J Vuillier, P Montcuquet, A Noir, A Rozenbaum, R Leconte des Floris |
Journal | British journal of haematology
(Br J Haematol)
Vol. 69
Issue 3
Pg. 345-9
(Jul 1988)
ISSN: 0007-1048 [Print] England |
PMID | 3044438
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Bone Marrow Transplantation
- Cell Separation
- Child
- Child, Preschool
- Family
- Female
- HLA Antigens
(analysis)
- Humans
- Immunosuppression Therapy
- Leukemia
(therapy)
- Male
- Pilot Projects
- T-Lymphocytes
- Tissue Donors
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